MolNFT v1 · #6278 · protein

Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.

1F7O · Pol polyprotein: “Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in…”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #6278 on GenesisL1: 3D structure, binding…

PDB: 1F7O
Type: protein
Length: 347 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pol polyprotein
EC: 3.6.1.23
UniProt: P16088
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pol polyprotein (EC 3.6.1.23)	protein	116	3% helix, 45% strand	P16088
C	Pol polyprotein (EC 3.6.1.23)	protein	115	3% helix, 50% strand	P16088

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	450	0.79	0.87	86	empty
2	118	0.45	0.77	19	empty
3	97	0.38	0.75	22	empty

Interfaces

3 interfaces between chains.

A–C · 1442 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 1401 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 1286 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1F7O · Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16088
Elsewhere: RCSB PDB 1F7O · PDBe 1F7O · UniProt P16088

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