MolNFT v1 · #6274 · protein

Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.

1F7K · Pol polyprotein: “Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in…”. X-ray diffraction, 2 ligands (UMP, MG), 1 pocket (best druggability 0.47). MolNFT v1 #6274 on GenesisL1…

PDB: 1F7K
Type: protein
Length: 234 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pol polyprotein
EC: 3.6.1.23
UniProt: P16088
Ligands: UMP, MG
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pol polyprotein (EC 3.6.1.23)	protein	117	3% helix, 40% strand	P16088

Ligands and binding sites

UMP · 2'-deoxyuridine 5'-monophosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.47	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 517 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1F7K · Crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16088
Elsewhere: RCSB PDB 1F7K · PDBe 1F7K · UniProt P16088

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