MolNFT v1 · #62689 · protein

The structure of cyanophycinase

3EN0: “The structure of cyanophycinase”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.79). MolNFT v1 #62689 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3EN0
Type: protein
Length: 791 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cyanophycinase
EC: 3.4.15.6
UniProt: P73832
Ligands: SO4
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 29% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cyanophycinase (EC 3.4.15.6)	protein	266	29% helix, 28% strand	P73832
B	Cyanophycinase (EC 3.4.15.6)	protein	265	30% helix, 29% strand	P73832
C	Cyanophycinase (EC 3.4.15.6)	protein	260	28% helix, 28% strand	P73832

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	951	0.79	0.81	80	empty
2	86	0.37	0.76	19	empty
3	65	0.37	0.78	17	empty

Interfaces

2 interfaces between chains.

A–B · 1521 Å² buried · 25 hydrogen bonds · protein-protein
B–C · 489 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

3EN0 · The Structure of Cyanophycinase · the same entry in another collection · chain A against A, TM-score 1.00
P73832 · AlphaFold monomer V2.0 prediction for cyanophycinase (P73832) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P73832
Elsewhere: RCSB PDB 3EN0 · PDBe 3EN0 · UniProt P73832

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