MolNFT v1 · #62509 · protein
Crystal structure of human osteoclast stimulating factor
3EHQ · Osteoclast-stimulating factor 1: “Crystal structure of human osteoclast stimulating factor”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1 #62509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3EHQ
- Type
- protein
- Length
- 363 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osteoclast-stimulating factor 1
- UniProt
- Q92882
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Osteoclast-stimulating factor 1 | protein | 182 | 36% helix, 16% strand | Q92882 |
| B | Osteoclast-stimulating factor 1 | protein | 181 | 38% helix, 16% strand | Q92882 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.44 | 0.74 | 25 | empty |
| 2 | 61 | 0.35 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 672 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92882
- Elsewhere: RCSB PDB 3EHQ · PDBe 3EHQ · UniProt Q92882
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