MolNFT v1 · #62429 · protein
Replacement of VAL3 in human thymidylate synthase affects its kinetic properties and intracellular stability
3EF9: “Replacement of VAL3 in human thymidylate synthase affects its kinetic properties and intracellular stability”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.60). MolNFT v1 #62429 on GenesisL1: 3D structure…
- PDB
- 3EF9
- Type
- protein
- Length
- 264 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thymidylate synthase
- EC
- 2.1.1.45
- UniProt
- P04818
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thymidylate synthase (EC 2.1.1.45) | protein | 264 | 30% helix, 20% strand | P04818 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 441 | 0.60 | 0.75 | 51 | SO4 |
| 2 | 50 | 0.32 | 0.77 | 13 | empty |
| 3 | 59 | 0.29 | 0.74 | 12 | empty |
Compared structures
- 3EF9 · Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04818
- Elsewhere: RCSB PDB 3EF9 · PDBe 3EF9 · UniProt P04818
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