MolNFT v1 · #62291 · protein

VIRA

3EB8 · Cysteine protease-like vira: “VIRA”. X-ray diffraction, 8 pockets (best druggability 0.85). MolNFT v1 #62291 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3EB8
Type: protein
Length: 670 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine protease-like vira
EC: 3.4.22.-
UniProt: Q7BU69
Pockets: 8 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine protease-like vira (EC 3.4.22.-)	protein	334	34% helix, 27% strand	Q7BU69
B	Cysteine protease-like vira (EC 3.4.22.-)	protein	336	32% helix, 27% strand	Q7BU69

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1095	0.85	0.87	81	empty
2	127	0.56	0.83	24	empty
3	272	0.51	0.75	41	empty
4	164	0.45	0.76	26	empty
5	161	0.42	0.74	21	empty

Interfaces

1 interface between chains.

A–B · 957 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

3EB8 · VirA · the same entry in another collection · chain A against A, TM-score 1.00
Q7BU69 · AlphaFold monomer V2.0 prediction for cysteine protease-like vira (Q7BU69) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7BU69
Elsewhere: RCSB PDB 3EB8 · PDBe 3EB8 · UniProt Q7BU69

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.