MolNFT v1 · #62229 · protein
Crystal structure long-form (RESIDUE1-124) of EAF3 chromo domain
3E9G · Chromatin modification-related protein EAF3: “Crystal structure long-form (RESIDUE1-124) of EAF3 chromo domain”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #62229 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3E9G
- Type
- protein
- Length
- 216 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin modification-related protein EAF3
- UniProt
- Q12432
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin modification-related protein EAF3 | protein | 107 | 25% helix, 33% strand | Q12432 |
| B | Chromatin modification-related protein EAF3 | protein | 109 | 28% helix, 33% strand | Q12432 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.34 | 0.74 | 18 | empty |
| 2 | 55 | 0.30 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 551 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3E9G · Crystal structure long-form (residue1-124) of Eaf3 chromo domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q12432 · AlphaFold monomer V2.0 prediction for chromatin modification-related protein EAF3 (Q12432) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12432
- Elsewhere: RCSB PDB 3E9G · PDBe 3E9G · UniProt Q12432
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