MolNFT v1 · #62163 · protein
Crystal structure of an antiparallel coiled-coil tetramerization domain from TRPM7 channels
3E7K: “Crystal structure of an antiparallel coiled-coil tetramerization domain from TRPM7 channels”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #62163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3E7K
- Type
- protein
- Length
- 432 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRPM7 channel
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 8 distinct chains · 95% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRPM7 channel | protein | 54 | 96% helix, 0% strand | — |
| B | TRPM7 channel | protein | 55 | 95% helix, 0% strand | — |
| C | TRPM7 channel | protein | 53 | 96% helix, 0% strand | — |
| D | TRPM7 channel | protein | 53 | 94% helix, 0% strand | — |
| E | TRPM7 channel | protein | 55 | 93% helix, 0% strand | — |
| F | TRPM7 channel | protein | 54 | 96% helix, 0% strand | — |
| G | TRPM7 channel | protein | 52 | 96% helix, 0% strand | — |
| H | TRPM7 channel | protein | 56 | 93% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 215 | 0.46 | 0.74 | 28 | empty |
Interfaces
14 interfaces between chains.
- E–H · 1322 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 1263 Ų buried · 6 hydrogen bonds · protein-protein
- F–G · 1258 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 1243 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1203 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3E7K · Crystal Structure of an antiparallel coiled-coil tetramerization domain from TRPM7… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3E7K · PDBe 3E7K
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