MolNFT v1 · #61948 · protein

Crystal structure of pyruvate kinase from leishmania mexicana

3E0W: “Crystal structure of pyruvate kinase from leishmania mexicana”. X-ray diffraction, 9 pockets (best druggability 0.76). MolNFT v1 #61948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3E0W
Type: protein
Length: 485 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pyruvate kinase
EC: 2.7.1.40
UniProt: Q27686
Pockets: 9 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pyruvate kinase (EC 2.7.1.40)	protein	485	36% helix, 22% strand	Q27686

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.76	0.95	27	empty
2	528	0.67	0.78	47	empty
3	371	0.58	0.76	35	empty
4	199	0.53	0.78	24	empty
5	100	0.52	0.82	20	empty

Compared structures

3E0W · Crystal structure of pyruvate kinase from Leishmania mexicana · the same entry in another collection · chain A against A, TM-score 1.00
Q27686 · AlphaFold monomer V2.0 prediction for pyruvate kinase (Q27686) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q27686
Elsewhere: RCSB PDB 3E0W · PDBe 3E0W · UniProt Q27686

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