MolNFT v1 · #61913 · protein
AED7-leukotriene E4 complex
3DZT · D7 protein: “AED7-leukotriene E4 complex”. X-ray diffraction, 2 ligands (EAH, CL), 4 pockets (best druggability 0.72). MolNFT v1 #61913 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3DZT
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- D7 protein
- UniProt
- P18153
- Ligands
- EAH, CL
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | D7 protein | protein | 298 | 58% helix, 3% strand | P18153 |
Ligands and binding sites
- EAH · (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid · ligand · chains A
- CL · Chloride ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.72 | 0.84 | 43 | CL, EAH |
| 2 | 56 | 0.71 | 0.98 | 16 | empty |
| 3 | 321 | 0.59 | 0.77 | 29 | GOL |
| 4 | 100 | 0.56 | 0.84 | 17 | TRS, GOL |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18153
- Elsewhere: RCSB PDB 3DZT · PDBe 3DZT · UniProt P18153
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