MolNFT v1 · #61582 · protein
Roccor domain tandem of rab family protein (roco)
3DPU: “Roccor domain tandem of rab family protein (roco)”. X-ray diffraction, 9 pockets (best druggability 0.68). MolNFT v1 #61582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3DPU
- Type
- protein
- Length
- 813 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rab family protein
- UniProt
- Q8KC98
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rab family protein | protein | 485 | 42% helix, 21% strand | Q8KC98 |
| B | Rab family protein | protein | 328 | 45% helix, 22% strand | Q8KC98 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 379 | 0.68 | 0.81 | 38 | empty |
| 2 | 220 | 0.63 | 0.82 | 38 | empty |
| 3 | 310 | 0.58 | 0.77 | 33 | empty |
| 4 | 105 | 0.54 | 0.83 | 23 | empty |
| 5 | 141 | 0.52 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1159 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3DPU · RocCOR domain tandem of Rab family protein (Roco) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8KC98
- Elsewhere: RCSB PDB 3DPU · PDBe 3DPU · UniProt Q8KC98
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