MolNFT v1 · #61546 · protein

Crystal structure of the complex of the CAF1M chaperone with the mini- fiber of two CAF1 subunits (CAF1:CAF1), carrying the THR7PHE and ALA9VAL mutations in the gd donor strand

3DOS · Chaperone protein CAF1M: “Crystal structure of the complex of the CAF1M chaperone with the mini- fiber of two CAF1 subunits…”. X-ray diffraction, 9 pockets (best druggability 0.59). MolNFT v1 #61546 on GenesisL1: 3D structure…

PDB: 3DOS
Type: protein
Length: 954 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chaperone protein CAF1M; F1 capsule antigen
UniProt: P26926, P26948
Pockets: 9 · best druggability 0.59

Structure

x-ray diffraction · 6 distinct chains · 3% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chaperone protein CAF1M	protein	201	3% helix, 56% strand	P26926
B	F1 capsule antigen	protein	147	2% helix, 50% strand	P26948
C	F1 capsule antigen	protein	135	2% helix, 47% strand	P26948
D	Chaperone protein CAF1M	protein	191	3% helix, 57% strand	P26926
E	F1 capsule antigen	protein	149	2% helix, 53% strand	P26948
F	F1 capsule antigen	protein	131	2% helix, 49% strand	P26948

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.59	0.82	41	empty
2	190	0.55	0.80	32	empty
3	296	0.55	0.76	45	empty
4	251	0.52	0.75	23	empty
5	264	0.51	0.75	44	empty

Interfaces

8 interfaces between chains.

D–E · 1749 Å² buried · 40 hydrogen bonds · protein-protein
A–B · 1669 Å² buried · 38 hydrogen bonds · protein-protein
B–C · 1263 Å² buried · 32 hydrogen bonds · protein-protein
E–F · 1224 Å² buried · 30 hydrogen bonds · protein-protein
B–D · 589 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3DOS · Crystal structure of the complex of the Caf1M chaperone with the mini-fiber of two Caf1… · the same entry in another collection · chain F against F, TM-score 1.00
P26926 · AlphaFold monomer V2.0 prediction for chaperone protein CAF1M (P26926) · a predicted model of the same protein · chain A against A, TM-score 0.99
P26948 · AlphaFold monomer V2.0 prediction for F1 capsule antigen (P26948) · a predicted model of the same protein · chain F against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26926
Every structure of UniProt P26948
Elsewhere: RCSB PDB 3DOS · PDBe 3DOS · UniProt P26926 · UniProt P26948

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