MolNFT v1 · #61313 · protein
Crystal structure of methionine importer metni
3DHW · D-methionine transport system permease protein meti: “Crystal structure of methionine importer metni”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #61313 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3DHW
- Type
- protein
- Length
- 2,184 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- D-methionine transport system permease protein meti; Methionine import ATP-binding…
- EC
- 3.6.3.-
- UniProt
- P31547, P30750
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, F | D-methionine transport system permease protein meti | protein | 203 | 77% helix, 0% strand | P31547 |
| C, D, G, H | Methionine import ATP-binding protein metn (EC 3.6.3.-) | protein | 343 | 36% helix, 30% strand | P30750 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 553 | 0.77 | 0.83 | 54 | empty |
| 2 | 634 | 0.74 | 0.80 | 54 | empty |
| 3 | 75 | 0.73 | 0.97 | 23 | empty |
| 4 | 624 | 0.71 | 0.79 | 64 | empty |
| 5 | 60 | 0.70 | 0.97 | 24 | empty |
Interfaces
9 interfaces between chains.
- G–H · 1893 Ų buried · 36 hydrogen bonds · protein-protein
- C–D · 1710 Ų buried · 27 hydrogen bonds · protein-protein
- E–F · 1607 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 1514 Ų buried · 7 hydrogen bonds · protein-protein
- E–G · 947 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3DHW · Crystal structure of methionine importer MetNI · the same entry in another collection · chain H against H, TM-score 1.00
- P31547 · AlphaFold monomer V2.0 prediction for D-methionine transport system permease protein meti… · a predicted model of the same protein · chain A against A, TM-score 0.91
- P30750 · AlphaFold monomer V2.0 prediction for methionine import ATP-binding protein metn (P30750) · a predicted model of the same protein · chain C against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31547
- Every structure of UniProt P30750
- Elsewhere: RCSB PDB 3DHW · PDBe 3DHW · UniProt P31547 · UniProt P30750
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