MolNFT v1 · #61233 · protein

Crystal structure of human prostasin

3DFJ: “Crystal structure of human prostasin”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.47). MolNFT v1 #61233 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3DFJ
Type: protein
Length: 248 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prostasin
EC: 3.4.21.-
UniProt: Q16651
Ligands: CL
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prostasin (EC 3.4.21.-)	protein	248	11% helix, 34% strand	Q16651

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	158	0.47	0.77	40	empty
2	55	0.32	0.76	15	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3DFJ · Crystal structure of human Prostasin · the same entry in another collection · chain A against A, TM-score 1.00
Q16651 · AlphaFold monomer V2.0 prediction for prostasin (Q16651) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16651
Elsewhere: RCSB PDB 3DFJ · PDBe 3DFJ · UniProt Q16651

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