MolNFT v1 · #61087 · protein
Crystal structure of methyltransferase domain of human pr domain- containing protein 4
3DB5 · Pr domain zinc finger protein 4: “Crystal structure of methyltransferase domain of human pr domain- containing protein 4”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #61087 on GenesisL1: 3D structure, binding…
- PDB
- 3DB5
- Type
- protein
- Length
- 258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pr domain zinc finger protein 4
- UniProt
- Q9UKN5
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pr domain zinc finger protein 4 | protein | 124 | 6% helix, 40% strand | Q9UKN5 |
| B | Pr domain zinc finger protein 4 | protein | 134 | 11% helix, 37% strand | Q9UKN5 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.49 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 228 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 3DB5 · Crystal structure of methyltransferase domain of human PR domain-containing protein 4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UKN5 · AlphaFold monomer V2.0 prediction for pr domain zinc finger protein 4 (Q9UKN5) · a predicted model of the same protein · chain A against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKN5
- Elsewhere: RCSB PDB 3DB5 · PDBe 3DB5 · UniProt Q9UKN5
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