MolNFT v1 · #61067 · protein
Methyltransferase domain of human pr domain-containing protein 1
3DAL · Pr domain zinc finger protein 1: “Methyltransferase domain of human pr domain-containing protein 1”. X-ray diffraction, 4 pockets (best druggability 0.49). MolNFT v1 #61067 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3DAL
- Type
- protein
- Length
- 345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pr domain zinc finger protein 1
- UniProt
- O75626
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pr domain zinc finger protein 1 | protein | 179 | 17% helix, 30% strand | O75626 |
| B | Pr domain zinc finger protein 1 | protein | 166 | 17% helix, 33% strand | O75626 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.49 | 0.77 | 23 | empty |
| 2 | 100 | 0.42 | 0.77 | 21 | empty |
| 3 | 58 | 0.38 | 0.80 | 19 | empty |
| 4 | 73 | 0.35 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 657 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3DAL · Methyltransferase domain of human PR domain-containing protein 1 · the same entry in another collection · chain A against A, TM-score 1.00
- O75626 · AlphaFold monomer V2.0 prediction for pr domain zinc finger protein 1 (O75626) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75626
- Elsewhere: RCSB PDB 3DAL · PDBe 3DAL · UniProt O75626
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