MolNFT v1 · #61028 · protein
Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxy-terminal domain of RNA-polymerase II
3D9I · RNA-binding protein 16: “Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxy-terminal…”. X-ray diffraction, 2 ligands (SO4, NH4), 2 pockets (best druggability 0.54). MolNFT v1 #61028…
- PDB
- 3D9I
- Type
- protein
- Length
- 278 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein 16
- UniProt
- Q9UPN6
- Ligands
- SO4, NH4
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-binding protein 16 | protein | 138 | 80% helix, 0% strand | Q9UPN6 |
| B | RNA-binding protein 16 | protein | 140 | 81% helix, 0% strand | Q9UPN6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 11 copies · chains A, B
- NH4 · Ammonium ion · ion · 6 copies · chains A, B
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.54 | 0.77 | 18 | SO4, GOL |
| 2 | 70 | 0.28 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 436 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3D9I · Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UPN6 · AlphaFold monomer V2.0 prediction for sr-related and ctd-associated factor 8 (Q9UPN6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UPN6
- Elsewhere: RCSB PDB 3D9I · PDBe 3D9I · UniProt Q9UPN6
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