MolNFT v1 · #61000 · protein
Uroporphyrinogen III synthase-uroporphyringen III complex
3D8N · Uroporphyrinogen-III synthase: “Uroporphyrinogen III synthase-uroporphyringen III complex”. X-ray diffraction, 1 ligand (UP3), 1 pocket (best druggability 0.68). MolNFT v1 #61000 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3D8N
- Type
- protein
- Length
- 250 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uroporphyrinogen-III synthase
- EC
- 4.2.1.75
- UniProt
- Q72KM1
- Ligands
- UP3
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uroporphyrinogen-III synthase (EC 4.2.1.75) | protein | 250 | 46% helix, 19% strand | Q72KM1 |
Ligands and binding sites
- UP3 · 3,3',3'',3'''-[3,8,13,17-tetrakis(carboxymethyl)porphyrin-2,7,12,18-tetrayl]tetrapropanoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.68 | 0.75 | 58 | UP3 |
Compared structures
- 3D8N · Uroporphyrinogen III Synthase-Uroporphyringen III Complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72KM1
- Elsewhere: RCSB PDB 3D8N · PDBe 3D8N · UniProt Q72KM1
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