MolNFT v1 · #60788 · protein

Structure of 2D9, a thermostable mutant of bacillus subtilis lipase obtained through directed evolution

3D2B: “Structure of 2D9, a thermostable mutant of bacillus subtilis lipase obtained through directed evolution”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #60788 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3D2B
Type: protein
Length: 358 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: P37957
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipase (EC 3.1.1.3)	protein	179	42% helix, 20% strand	P37957

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.40	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 462 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

3D2B · Structure of 2D9, a thermostable mutant of Bacillus subtilis lipase obtained through… · the same entry in another collection · chain A against A, TM-score 1.00
P37957 · AlphaFold monomer V2.0 prediction for lipase esta (P37957) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37957
Elsewhere: RCSB PDB 3D2B · PDBe 3D2B · UniProt P37957

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