MolNFT v1 · #6078 · protein

Crystal structure of streptococcus agalactiae hyaluronate lyase at 2.1 ångström resolution.

1F1S: “Crystal structure of streptococcus agalactiae hyaluronate lyase at 2.1 ångström resolution.”. X-ray diffraction, 10 pockets (best druggability 0.67). MolNFT v1 #6078 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1F1S
Type: protein
Length: 814 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hyaluronate lyase
EC: 4.2.2.1
UniProt: Q53591
Pockets: 10 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hyaluronate lyase (EC 4.2.2.1)	protein	814	33% helix, 28% strand	Q53591

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	576	0.67	0.77	72	empty
2	323	0.64	0.80	21	empty
3	239	0.52	0.76	29	empty
4	171	0.46	0.75	23	empty
5	54	0.45	0.84	24	empty

Compared structures

1F1S · Crystal structure of streptococcus agalactiae hyaluronate lyase at 2.1 ångström… · the same entry in another collection · chain A against A, TM-score 1.00
Q53591 · AlphaFold monomer V2.0 prediction for hyaluronate lyase (Q53591) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53591
Elsewhere: RCSB PDB 1F1S · PDBe 1F1S · UniProt Q53591

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