MolNFT v1 · #60768 · protein + DNA
Structure of human brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
3D1N · 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*D…: “Structure of human brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter”. X-ray diffraction, 20 pockets (best druggability 0.75).…
- PDB
- 3D1N
- Type
- protein + DNA
- Length
- 1,110 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*D a)-3'…
- UniProt
- Q14863
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 7 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*D a)-3' | dna | 14 | — | — |
| B, D, F, H | 5'-D(*DTP*DTP*DAP*DTP*DTP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DCP*D T)-3' | dna | 14 | — | — |
| I, K, M, O | Pou domain, class 6, transcription factor 1 | protein | 150 | 67% helix, 0% strand | Q14863 |
| J | Pou domain, class 6, transcription factor 1 | protein | 86 | 83% helix, 0% strand | Q14863 |
| L | Pou domain, class 6, transcription factor 1 | protein | 145 | 72% helix, 1% strand | Q14863 |
| N | Pou domain, class 6, transcription factor 1 | protein | 85 | 80% helix, 0% strand | Q14863 |
| P | Pou domain, class 6, transcription factor 1 | protein | 82 | 77% helix, 0% strand | Q14863 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.75 | 0.85 | 47 | empty |
| 2 | 985 | 0.75 | 0.78 | 72 | empty |
| 3 | 434 | 0.71 | 0.82 | 49 | empty |
| 4 | 548 | 0.67 | 0.78 | 48 | empty |
| 5 | 471 | 0.67 | 0.79 | 38 | empty |
Interfaces
37 interfaces between chains.
- E–M · 832 Ų buried · 22 hydrogen bonds · protein-nucleic
- A–I · 822 Ų buried · 21 hydrogen bonds · protein-nucleic
- G–O · 790 Ų buried · 19 hydrogen bonds · protein-nucleic
- C–K · 755 Ų buried · 17 hydrogen bonds · protein-nucleic
- E–F · 668 Ų buried · 64 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 29 modified (engineered).
Compared structures
- 3D1N · Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing… · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14863
- Elsewhere: RCSB PDB 3D1N · PDBe 3D1N · UniProt Q14863
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