MolNFT v1 · #60564 · protein
How TCR-like antibody recognizes MHC-bound peptide
3CVI · 25-D1.16 heavy chain: “How TCR-like antibody recognizes MHC-bound peptide”. X-ray diffraction, 1 pocket (best druggability 0.62). MolNFT v1 #60564 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CVI
- Type
- protein
- Length
- 422 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 25-D1.16 heavy chain; 25-D1.16 light chain
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 25-D1.16 heavy chain | protein | 213 | 8% helix, 51% strand | — |
| L | 25-D1.16 light chain | protein | 209 | 6% helix, 50% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.62 | 0.76 | 58 | empty |
Interfaces
1 interface between chains.
- H–L · 1661 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3CVI · How TCR-like antibody recognizes MHC-bound peptide · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3CVI · PDBe 3CVI
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