MolNFT v1 · #60556 · protein

Human BCL-xl containing a TRP to ala mutation at position 137

3CVA · Apoptosis regulator BCL-X: “Human BCL-xl containing a TRP to ala mutation at position 137”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #60556 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CVA
Type: protein
Length: 141 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis regulator BCL-X
UniProt: Q07817
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Apoptosis regulator BCL-X	protein	141	72% helix, 0% strand	Q07817

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.37	0.78	16	empty

Compared structures

3CVA · Human Bcl-xL containing a Trp to Ala mutation at position 137 · the same entry in another collection · chain X against X, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain X against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 3CVA · PDBe 3CVA · UniProt Q07817

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