MolNFT v1 · #60252 · protein

A RNA polymerase subunit structure from virus

3CM8 · Polymerase acidic protein: “A RNA polymerase subunit structure from virus”. X-ray diffraction, 7 pockets (best druggability 0.71). MolNFT v1 #60252 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CM8
Type: protein
Length: 451 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase acidic protein; Peptide from RNA-directed RNA polymerase catalytic subunit
EC: 2.7.7.48
UniProt: Q9EA60, Q9WLS3
Pockets: 7 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase acidic protein	protein	435	40% helix, 20% strand	Q9EA60
B	Peptide from RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	16	38% helix, 13% strand	Q9WLS3

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	518	0.71	0.80	55	empty
2	151	0.53	0.80	25	empty
3	85	0.49	0.83	24	empty
4	103	0.41	0.76	8	empty
5	84	0.40	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 1176 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3CM8 · A RNA polymerase subunit structure from virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EA60
Every structure of UniProt Q9WLS3
Elsewhere: RCSB PDB 3CM8 · PDBe 3CM8 · UniProt Q9EA60 · UniProt Q9WLS3

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