MolNFT v1 · #60158 · protein

TIM8-TIM13 complex

3CJH · Mitochondrial import inner membrane translocase subunit…: “TIM8-TIM13 complex”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #60158 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CJH
Type: protein
Length: 659 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial import inner…
UniProt: P53299, P57744
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 6 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, K	Mitochondrial import inner membrane translocase subunit TIM13	protein	52	73% helix, 0% strand	P53299
B	Mitochondrial import inner membrane translocase subunit TIM8	protein	59	78% helix, 0% strand	P57744
D	Mitochondrial import inner membrane translocase subunit TIM8	protein	55	78% helix, 0% strand	P57744
F, H, L	Mitochondrial import inner membrane translocase subunit TIM8	protein	58	74% helix, 0% strand	P57744
I	Mitochondrial import inner membrane translocase subunit TIM13	protein	54	69% helix, 0% strand	P53299
J	Mitochondrial import inner membrane translocase subunit TIM8	protein	57	77% helix, 0% strand	P57744

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	847	0.78	0.81	87	empty
2	118	0.41	0.75	21	empty
3	80	0.34	0.75	20	empty
4	71	0.34	0.76	16	empty
5	58	0.33	0.77	18	empty

Interfaces

23 interfaces between chains.

I–J · 1345 Å² buried · 16 hydrogen bonds · protein-protein
G–H · 1335 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 1326 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 1306 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 1303 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 24 disulfide (disulfide).

Compared structures

3CJH · Tim8-Tim13 complex · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53299
Every structure of UniProt P57744
Elsewhere: RCSB PDB 3CJH · PDBe 3CJH · UniProt P53299 · UniProt P57744

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