MolNFT v1 · #60069 · protein

Crystal structure of unliganded argos

3CGU · Protein giant-lens: “Crystal structure of unliganded argos”. X-ray diffraction, 8 pockets (best druggability 0.69). MolNFT v1 #60069 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CGU
Type: protein
Length: 412 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein giant-lens
UniProt: Q00805
Pockets: 8 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein giant-lens	protein	207	4% helix, 43% strand	Q00805
B	Protein giant-lens	protein	205	1% helix, 44% strand	Q00805

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.69	0.88	43	empty
2	197	0.60	0.81	37	empty
3	176	0.54	0.79	32	empty
4	158	0.53	0.79	33	empty
5	189	0.53	0.78	32	empty

Interfaces

1 interface between chains.

A–B · 1560 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

3CGU · Crystal Structure of unliganded Argos · the same entry in another collection · chain A against A, TM-score 1.00
Q00805 · AlphaFold monomer V2.0 prediction for protein giant-lens (Q00805) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00805
Elsewhere: RCSB PDB 3CGU · PDBe 3CGU · UniProt Q00805

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