MolNFT v1 · #59951 · protein
Ki O18/O8 N34I/Y87H immunoglobulin light chain variable domain
3CDC · Light chain amyloidogenic: “Ki O18/O8 N34I/Y87H immunoglobulin light chain variable domain”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #59951 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CDC
- Type
- protein
- Length
- 218 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Light chain amyloidogenic
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 3% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Light chain amyloidogenic | protein | 109 | 3% helix, 50% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.43 | 0.76 | 30 | empty |
| 2 | 97 | 0.39 | 0.76 | 18 | empty |
| 3 | 74 | 0.34 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 802 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3CDC · kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3CDC · PDBe 3CDC
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