MolNFT v1 · #59816 · protein
Structural basis of histone H4 recognition by P55
3C9C · Chromatin assembly factor 1 P55 subunit: “Structural basis of histone H4 recognition by P55”. X-ray diffraction, 1 ligand (CD), 4 pockets (best druggability 0.76). MolNFT v1 #59816 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3C9C
- Type
- protein
- Length
- 391 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin assembly factor 1 P55 subunit; Histone H4, 27-residue peptide
- UniProt
- Q24572, P84040
- Ligands
- CD
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin assembly factor 1 P55 subunit | protein | 380 | 9% helix, 42% strand | Q24572 |
| B | Histone H4, 27-residue peptide | protein | 11 | 64% helix, 0% strand | P84040 |
Ligands and binding sites
- CD · Cadmium ion · metal · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 489 | 0.76 | 0.84 | 32 | CD |
| 2 | 98 | 0.53 | 0.84 | 18 | empty |
| 3 | 108 | 0.49 | 0.81 | 22 | empty |
| 4 | 90 | 0.37 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 654 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3C9C · Structural Basis of Histone H4 Recognition by p55 · the same entry in another collection · chain A against A, TM-score 1.00
- Q24572 · AlphaFold monomer V2.0 prediction for chromatin assembly factor 1 P55 subunit (Q24572) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P84040 · AlphaFold monomer V2.0 prediction for histone H4 (P84040) · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q24572
- Every structure of UniProt P84040
- Elsewhere: RCSB PDB 3C9C · PDBe 3C9C · UniProt Q24572 · UniProt P84040
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