MolNFT v1 · #59812 · protein
Revised structure of the MUNC18A-SYNTAXIN1 complex
3C98 · Syntaxin-binding protein 1: “Revised structure of the MUNC18A-SYNTAXIN1 complex”. X-ray diffraction, 10 pockets (best druggability 0.72). MolNFT v1 #59812 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3C98
- Type
- protein
- Length
- 786 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Syntaxin-binding protein 1; Syntaxin-1A
- UniProt
- P61765, P32851
- Pockets
- 10 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Syntaxin-binding protein 1 | protein | 556 | 46% helix, 15% strand | P61765 |
| B | Syntaxin-1A | protein | 230 | 72% helix, 0% strand | P32851 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 751 | 0.72 | 0.78 | 80 | empty |
| 2 | 326 | 0.70 | 0.83 | 36 | empty |
| 3 | 278 | 0.65 | 0.82 | 45 | empty |
| 4 | 176 | 0.56 | 0.80 | 30 | empty |
| 5 | 203 | 0.52 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2653 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 3C98 · Revised structure of the munc18a-syntaxin1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P61765 · AlphaFold monomer V2.0 prediction for syntaxin-binding protein 1 (P61765) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P32851 · AlphaFold monomer V2.0 prediction for syntaxin-1A (P32851) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61765
- Every structure of UniProt P32851
- Elsewhere: RCSB PDB 3C98 · PDBe 3C98 · UniProt P61765 · UniProt P32851
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