MolNFT v1 · #5970 · protein + DNA
Crystal structure of chymotryptic fragment of E. COLI ssb bound to two 35-mer single strand dnas
1EYG · Single stranded 28-mer of D(C): “Crystal structure of chymotryptic fragment of E. COLI ssb bound to two 35-mer single strand dnas”. X-ray diffraction, 8 pockets (best druggability 0.65). MolNFT v1 #5970 on GenesisL1: 3D structure…
- PDB
- 1EYG
- Type
- protein + DNA
- Length
- 491 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single stranded 28-mer of D(C); Single-strand DNA-binding protein
- UniProt
- P0AGE0
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 5 distinct chains · 9% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| Q | Single stranded 28-mer of D(C) | dna | 28 | — | — |
| R | Single stranded 28-mer of D(C) | dna | 23 | — | — |
| A, C | Single-strand DNA-binding protein | protein | 112 | 9% helix, 52% strand | P0AGE0 |
| B | Single-strand DNA-binding protein | protein | 104 | 10% helix, 58% strand | P0AGE0 |
| D | Single-strand DNA-binding protein | protein | 112 | 9% helix, 49% strand | P0AGE0 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 285 | 0.65 | 0.82 | 35 | empty |
| 2 | 143 | 0.63 | 0.86 | 31 | empty |
| 3 | 89 | 0.56 | 0.86 | 21 | empty |
| 4 | 136 | 0.50 | 0.80 | 17 | empty |
| 5 | 142 | 0.43 | 0.75 | 25 | empty |
Interfaces
13 interfaces between chains.
- Q–D · 1714 Ų buried · 53 hydrogen bonds · protein-nucleic
- Q–C · 1712 Ų buried · 67 hydrogen bonds · protein-nucleic
- C–D · 1349 Ų buried · 34 hydrogen bonds · protein-protein
- R–B · 1340 Ų buried · 41 hydrogen bonds · protein-nucleic
- R–A · 1335 Ų buried · 46 hydrogen bonds · protein-nucleic
Compared structures
- 1EYG · Crystal structure of chymotryptic fragment of E. coli ssb bound to two 35-mer single… · the same entry in another collection · chain D against D, TM-score 1.00
- P0AGE0 · AlphaFold monomer V2.0 prediction for single-stranded DNA-binding protein (P0AGE0) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AGE0
- Elsewhere: RCSB PDB 1EYG · PDBe 1EYG · UniProt P0AGE0
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