MolNFT v1 · #59646 · RNA
Crystal structure of HIV-1 subtype F dis extended duplex RNA bound to paromomycin
3C44 · HIV-1 subtype F genomic RNA: “Crystal structure of HIV-1 subtype F dis extended duplex RNA bound to paromomycin”. X-ray diffraction, 3 ligands (PAR, K, CL), 1 pocket (best druggability 0.67). MolNFT v1 #59646 on GenesisL1: 3D…
- PDB
- 3C44
- Type
- RNA
- Length
- 46 nucleotides
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 subtype F genomic RNA
- Ligands
- PAR, K, CL
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | HIV-1 subtype F genomic RNA | rna | 23 | — | — |
Ligands and binding sites
- PAR · Paromomycin · ligand · 2 copies · chains A, B
- K · Potassium ion · metal · 4 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 954 | 0.67 | 0.74 | 42 | PAR, K |
Interfaces
1 interface between chains.
- A–B · 1238 Ų buried · 115 hydrogen bonds · nucleic-nucleic
Compared structures
- 3C44 · Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to paromomycin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3C44 · PDBe 3C44
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.