MolNFT v1 · #59597 · protein

Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from sachharomyces cerevisiae complexed with quinolinate

3C2O · Nicotinate-nucleotide pyrophosphorylase: “Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from sachharomyces cerevisiae…”. X-ray diffraction, 1 ligand (NTM), 2 pockets (best druggability 0.49). MolNFT v1…

PDB: 3C2O
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nicotinate-nucleotide pyrophosphorylase
EC: 2.4.2.19
UniProt: P43619
Ligands: NTM
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nicotinate-nucleotide pyrophosphorylase (EC 2.4.2.19)	protein	265	42% helix, 20% strand	P43619

Ligands and binding sites

NTM · Quinolinic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.49	0.83	13	empty
2	80	0.37	0.77	14	NTM

Compared structures

3C2O · Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from Sachharomyces… · the same entry in another collection · chain A against A, TM-score 1.00
P43619 · AlphaFold monomer V2.0 prediction for nicotinate-nucleotide pyrophosphorylase… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43619
Elsewhere: RCSB PDB 3C2O · PDBe 3C2O · UniProt P43619

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