MolNFT v1 · #59589 · protein
Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from saccharomyces cerevisiae complexed with prpp
3C2F · Nicotinate-nucleotide pyrophosphorylase: “Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from saccharomyces cerevisiae…”. X-ray diffraction, 1 ligand (PRP), 5 pockets (best druggability 0.58). MolNFT v1…
- PDB
- 3C2F
- Type
- protein
- Length
- 267 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinate-nucleotide pyrophosphorylase
- EC
- 2.4.2.19
- UniProt
- P43619
- Ligands
- PRP
- Pockets
- 5 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinate-nucleotide pyrophosphorylase (EC 2.4.2.19) | protein | 267 | 41% helix, 20% strand | P43619 |
Ligands and binding sites
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.58 | 0.85 | 17 | empty |
| 2 | 130 | 0.43 | 0.77 | 21 | PRP |
| 3 | 65 | 0.34 | 0.76 | 11 | empty |
| 4 | 57 | 0.30 | 0.75 | 14 | empty |
| 5 | 54 | 0.26 | 0.72 | 21 | empty |
Compared structures
- 3C2F · Crystal structure of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces… · the same entry in another collection · chain A against A, TM-score 1.00
- P43619 · AlphaFold monomer V2.0 prediction for nicotinate-nucleotide pyrophosphorylase… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43619
- Elsewhere: RCSB PDB 3C2F · PDBe 3C2F · UniProt P43619
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.