MolNFT v1 · #59574 · protein

Structure of the ligand-free form of a bacterial DNA damage sensor protein

3C1Z · DNA integrity scanning protein disa: “Structure of the ligand-free form of a bacterial DNA damage sensor protein”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #59574 on GenesisL1: 3D structure, binding sites and…

PDB: 3C1Z
Type: protein
Length: 698 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA integrity scanning protein disa
UniProt: Q9WY43
Pockets: 5 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA integrity scanning protein disa	protein	349	58% helix, 13% strand	Q9WY43

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	765	0.77	0.82	67	empty
2	135	0.45	0.77	24	empty
3	112	0.42	0.76	24	empty
4	56	0.28	0.74	18	empty
5	50	0.26	0.74	10	empty

Interfaces

1 interface between chains.

A–B · 418 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3C1Z · Structure of the ligand-free form of a bacterial DNA damage sensor protein · the same entry in another collection · chain A against A, TM-score 1.00
Q9WY43 · AlphaFold monomer V2.0 prediction for DNA integrity scanning protein disa (Q9WY43) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WY43
Elsewhere: RCSB PDB 3C1Z · PDBe 3C1Z · UniProt Q9WY43

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