MolNFT v1 · #5952 · protein + RNA

Solution structure of HTLV-1 peptide bound to its RNA aptamer target

1EXY · RNA aptamer, 33-mer: “Solution structure of HTLV-1 peptide bound to its RNA aptamer target”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #5952 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1EXY
Type: protein + RNA
Length: 49 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA aptamer, 33-mer; HTLV-1 rex peptide
UniProt: O56230
Pockets: 1 · best druggability 0.35

Structure

solution nmr · 2 distinct chains · 19% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA aptamer, 33-mer	rna	33	—	—
B	HTLV-1 rex peptide	protein	16	19% helix, 0% strand	O56230

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.35	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1144 Å² buried · 40 hydrogen bonds · protein-nucleic

Compared structures

1EXY · Solution structure of HTLV-1 peptide bound to its RNA aptamer target · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O56230
Elsewhere: RCSB PDB 1EXY · PDBe 1EXY · UniProt O56230

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