MolNFT v1 · #59511 · protein
Crystal structure of a tetr family transcriptional regulator from streptomyces coelicolor A3(2)
3C07 · Putative tetr-family transcriptional regulator: “Crystal structure of a tetr family transcriptional regulator from streptomyces coelicolor A3(2)”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.90). MolNFT v1…
- PDB
- 3C07
- Type
- protein
- Length
- 435 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative tetr-family transcriptional regulator
- UniProt
- Q9KZ96
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.90
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative tetr-family transcriptional regulator | protein | 221 | 73% helix, 0% strand | Q9KZ96 |
| B | Putative tetr-family transcriptional regulator | protein | 214 | 76% helix, 0% strand | Q9KZ96 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.90 | 0.92 | 124 | empty |
| 2 | 62 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1664 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 3C07 · Crystal structure of a TetR family transcriptional regulator from Streptomyces coelicolor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KZ96
- Elsewhere: RCSB PDB 3C07 · PDBe 3C07 · UniProt Q9KZ96
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