MolNFT v1 · #59298 · protein
Crystal structure of the super-repressor mutant of GAL80P from saccharomyces cerevisiae; GAL80(S0)-[G301R]
3BTV · GALACTOSE/LACTOSE metabolism regulatory protein GAL80: “Crystal structure of the super-repressor mutant of GAL80P from saccharomyces cerevisiae; GAL80(S0)-[G301R]”. X-ray diffraction, 11 pockets (best druggability 0.76). MolNFT v1…
- PDB
- 3BTV
- Type
- protein
- Length
- 782 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GALACTOSE/LACTOSE metabolism regulatory protein GAL80
- UniProt
- P04387
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 390 | 32% helix, 27% strand | P04387 |
| B | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 392 | 32% helix, 27% strand | P04387 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 888 | 0.76 | 0.80 | 88 | empty |
| 2 | 580 | 0.71 | 0.79 | 46 | empty |
| 3 | 700 | 0.69 | 0.76 | 50 | empty |
| 4 | 170 | 0.46 | 0.75 | 23 | empty |
| 5 | 134 | 0.43 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1635 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3BTV · Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae… · the same entry in another collection · chain A against A, TM-score 1.00
- P04387 · AlphaFold monomer V2.0 prediction for GALACTOSE/LACTOSE metabolism regulatory protein… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04387
- Elsewhere: RCSB PDB 3BTV · PDBe 3BTV · UniProt P04387
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