MolNFT v1 · #59297 · protein
Crystal structure of the super-repressor mutant of GAL80P from saccharomyces cerevisiae; GAL80(S2) [E351K]
3BTU · GALACTOSE/LACTOSE metabolism regulatory protein GAL80: “Crystal structure of the super-repressor mutant of GAL80P from saccharomyces cerevisiae; GAL80(S2) [E351K]”. X-ray diffraction, 18 pockets (best druggability 0.77). MolNFT v1…
- PDB
- 3BTU
- Type
- protein
- Length
- 2,335 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GALACTOSE/LACTOSE metabolism regulatory protein GAL80
- UniProt
- P04387
- Pockets
- 18 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 392 | 35% helix, 25% strand | P04387 |
| B | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 389 | 35% helix, 25% strand | P04387 |
| C | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 388 | 35% helix, 25% strand | P04387 |
| E, F | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 387 | 33% helix, 20% strand | P04387 |
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 988 | 0.77 | 0.79 | 78 | empty |
| 2 | 171 | 0.75 | 0.93 | 28 | empty |
| 3 | 199 | 0.75 | 0.91 | 28 | empty |
| 4 | 176 | 0.75 | 0.92 | 27 | empty |
| 5 | 630 | 0.72 | 0.80 | 70 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1953 Ų buried · 38 hydrogen bonds · protein-protein
- E–F · 1942 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 1898 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 617 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 108 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3BTU · Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae… · the same entry in another collection · chain F against F, TM-score 1.00
- P04387 · AlphaFold monomer V2.0 prediction for GALACTOSE/LACTOSE metabolism regulatory protein… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04387
- Elsewhere: RCSB PDB 3BTU · PDBe 3BTU · UniProt P04387
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