MolNFT v1 · #58782 · protein
Human CD94/NKG2A
3BDW · Natural killer cells antigen CD94: “Human CD94/NKG2A”. X-ray diffraction, 7 pockets (best druggability 0.52). MolNFT v1 #58782 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3BDW
- Type
- protein
- Length
- 477 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Natural killer cells antigen CD94; NKG2-A/NKG2-B type II integral membrane protein
- UniProt
- Q13241, P26715
- Pockets
- 7 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Natural killer cells antigen CD94 | protein | 123 | 18% helix, 32% strand | Q13241 |
| B, D | NKG2-A/NKG2-B type II integral membrane protein | protein | 116 | 17% helix, 33% strand | P26715 |
| C | Natural killer cells antigen CD94 | protein | 122 | 18% helix, 32% strand | Q13241 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.52 | 0.79 | 29 | empty |
| 2 | 114 | 0.43 | 0.77 | 23 | empty |
| 3 | 103 | 0.40 | 0.76 | 24 | empty |
| 4 | 56 | 0.34 | 0.78 | 16 | empty |
| 5 | 55 | 0.33 | 0.77 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 784 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 775 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 277 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 3BDW · Human CD94/NKG2A · the same entry in another collection · chain A against A, TM-score 1.00
- Q13241 · AlphaFold monomer V2.0 prediction for natural killer cells antigen CD94 (Q13241) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P26715 · AlphaFold monomer V2.0 prediction for NKG2-A/NKG2-B type II integral membrane protein… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13241
- Every structure of UniProt P26715
- Elsewhere: RCSB PDB 3BDW · PDBe 3BDW · UniProt Q13241 · UniProt P26715
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