MolNFT v1 · #58512 · protein
Actin filament model in the extended form of acromsomal bundle in the limulus sperm
3B63: “Actin filament model in the extended form of acromsomal bundle in the limulus sperm”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #58512 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3B63
- Type
- protein
- Length
- 5,093 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 7 distinct chains · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Actin | protein | 365 | 41% helix, 20% strand | — |
| B | Actin | protein | 364 | 42% helix, 20% strand | — |
| C, I | Actin | protein | 365 | 43% helix, 20% strand | — |
| D | Actin | protein | 357 | 39% helix, 18% strand | — |
| E, H, J, K, N | Actin | protein | 365 | 42% helix, 19% strand | — |
| F | Actin | protein | 357 | 41% helix, 19% strand | — |
| L, M | Actin | protein | 365 | 37% helix, 20% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1006 | 0.86 | 0.87 | 139 | empty |
| 2 | 1162 | 0.82 | 0.83 | 135 | empty |
| 3 | 1025 | 0.81 | 0.82 | 105 | empty |
| 4 | 1183 | 0.79 | 0.81 | 98 | empty |
| 5 | 262 | 0.79 | 0.91 | 58 | empty |
Interfaces
25 interfaces between chains.
- I–J · 1187 Ų buried · 32 hydrogen bonds · protein-protein
- M–N · 1120 Ų buried · 11 hydrogen bonds · protein-protein
- L–M · 1085 Ų buried · 13 hydrogen bonds · protein-protein
- K–L · 1061 Ų buried · 30 hydrogen bonds · protein-protein
- E–F · 989 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3B63 · Actin filament model in the extended form of acromsomal bundle in the Limulus sperm · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3B63 · PDBe 3B63
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