MolNFT v1 · #58462 · protein
Crystal structure of human PABPN1 rrm
3B4M · Polyadenylate-binding protein 2: “Crystal structure of human PABPN1 rrm”. X-ray diffraction, 1 pocket (best druggability 0.52). MolNFT v1 #58462 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3B4M
- Type
- protein
- Length
- 319 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyadenylate-binding protein 2
- UniProt
- Q86U42
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Polyadenylate-binding protein 2 | protein | 80 | 26% helix, 40% strand | Q86U42 |
| D | Polyadenylate-binding protein 2 | protein | 79 | 25% helix, 37% strand | Q86U42 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 287 | 0.52 | 0.75 | 57 | empty |
Interfaces
5 interfaces between chains.
- A–B · 821 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 819 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 173 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 55 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 52 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86U42
- Elsewhere: RCSB PDB 3B4M · PDBe 3B4M · UniProt Q86U42
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