MolNFT v1 · #5838 · protein

A novel anti-tumor cytokine contains a RNA-binding motif present in aminoacyl-tRNA synthetases

1EUJ · Endothelial monocyte activating polypeptide 2: “A novel anti-tumor cytokine contains a RNA-binding motif present in aminoacyl-tRNA synthetases”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #5838 on GenesisL1: 3D…

PDB: 1EUJ
Type: protein
Length: 328 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endothelial monocyte activating polypeptide 2
UniProt: Q12904
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Endothelial monocyte activating polypeptide 2	protein	164	10% helix, 41% strand	Q12904

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.47	0.77	29	empty
2	62	0.39	0.79	12	empty
3	85	0.38	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 582 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

1EUJ · A novel anti-tumor cytokine contains a RNA-binding motif present in aminoacyl-tRNA… · the same entry in another collection · chain A against A, TM-score 1.00
Q12904 · AlphaFold monomer V2.0 prediction for aminoacyl tRNA synthase complex-interacting… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12904
Elsewhere: RCSB PDB 1EUJ · PDBe 1EUJ · UniProt Q12904

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