MolNFT v1 · #58314 · protein

Crystal structure of puromycin hydrolase S511A mutant

3AZP · Aminopeptidase: “Crystal structure of puromycin hydrolase S511A mutant”. X-ray diffraction, 1 ligand (SO4), 9 pockets (best druggability 0.83). MolNFT v1 #58314 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3AZP
Type: protein
Length: 1,322 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase
UniProt: Q2HXD9
Ligands: SO4
Pockets: 9 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Aminopeptidase	protein	661	16% helix, 33% strand	Q2HXD9

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1199	0.83	0.84	104	empty
2	1125	0.83	0.84	100	empty
3	1134	0.80	0.82	66	empty
4	473	0.71	0.81	81	empty
5	479	0.67	0.78	36	empty

Interfaces

1 interface between chains.

A–B · 670 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

3AZP · Crystal structure of puromycin hydrolase S511A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2HXD9
Elsewhere: RCSB PDB 3AZP · PDBe 3AZP · UniProt Q2HXD9

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