MolNFT v1 · #58257 · protein

Structure of florigen activation complex consisting of rice florigen HD3A, 14-3-3 protein GF14 and rice fd homolog OSFD1

3AXY · Protein heading date 3A: “Structure of florigen activation complex consisting of rice florigen HD3A, 14-3-3 protein GF14 and rice fd…”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #58257 on GenesisL1: 3D…

PDB: 3AXY
Type: protein
Length: 1,630 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein heading date 3A; 14-3-3-like protein GF14-C; Rice fd homolog OSFD1
UniProt: Q93WI9, Q6ZKC0
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 5 distinct chains · 55% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, H	Protein heading date 3A	protein	166	13% helix, 32% strand	Q93WI9
C, D, I	14-3-3-like protein GF14-C	protein	235	85% helix, 0% strand	Q6ZKC0
E, F, K, L	Rice fd homolog OSFD1	protein	7	0% helix, 0% strand	—
G	Protein heading date 3A	protein	165	13% helix, 33% strand	Q93WI9
J	14-3-3-like protein GF14-C	protein	234	85% helix, 0% strand	Q6ZKC0

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	986	0.82	0.83	86	empty
2	717	0.81	0.85	71	empty
3	885	0.71	0.76	86	empty
4	260	0.66	0.83	33	empty
5	196	0.66	0.85	31	empty

Interfaces

22 interfaces between chains.

C–D · 1213 Å² buried · 13 hydrogen bonds · protein-protein
I–J · 1182 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 705 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 677 Å² buried · 8 hydrogen bonds · protein-protein
H–J · 674 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (phosphorylation).

Compared structures

3AXY · Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93WI9
Every structure of UniProt Q6ZKC0
Elsewhere: RCSB PDB 3AXY · PDBe 3AXY · UniProt Q93WI9 · UniProt Q6ZKC0

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