MolNFT v1 · #58221 · protein
Crystal structure of rat TOM20-aldh presequence complex: the intermolecular disulfide bond was cleaved in the crystal of a disulfide-tethered complex.
3AWR · Mitochondrial import receptor subunit TOM20 homolog: “Crystal structure of rat TOM20-aldh presequence complex: the intermolecular disulfide bond was cleaved in the…”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1…
- PDB
- 3AWR
- Type
- protein
- Length
- 161 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial import receptor subunit TOM20 homolog; Aldehyde dehydrogenase, mitochondrial
- UniProt
- Q62760, P11884
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial import receptor subunit TOM20 homolog | protein | 73 | 78% helix, 0% strand | Q62760 |
| B | Mitochondrial import receptor subunit TOM20 homolog | protein | 64 | 80% helix, 0% strand | Q62760 |
| C, D | Aldehyde dehydrogenase, mitochondrial | protein | 12 | 83% helix, 0% strand | P11884 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.38 | 0.74 | 24 | empty |
Interfaces
4 interfaces between chains.
- A–B · 615 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 489 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 412 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 48 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3AWR · Crystal structure of Rat TOM20-ALDH presequence complex: The intermolecular disulfide… · the same entry in another collection · chain D against D, TM-score 1.00
- Q62760 · AlphaFold monomer V2.0 prediction for mitochondrial import receptor subunit TOM20 homolog… · a predicted model of the same protein · chain B against A, TM-score 0.84
- P11884 · AlphaFold monomer V2.0 prediction for aldehyde dehydrogenase, mitochondrial (P11884) · a predicted model of the same protein · chain D against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62760
- Every structure of UniProt P11884
- Elsewhere: RCSB PDB 3AWR · PDBe 3AWR · UniProt Q62760 · UniProt P11884
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