MolNFT v1 · #58203 · protein

Structure of a multicopper oxidase from the hyperthermophilic archaeon pyrobaculum aerophilum

3AW5: “Structure of a multicopper oxidase from the hyperthermophilic archaeon pyrobaculum aerophilum”. X-ray diffraction, 2 ligands (C2O, CU), 3 pockets (best druggability 0.52). MolNFT v1 #58203 on GenesisL1: 3D structure, binding sites…

PDB: 3AW5
Type: protein
Length: 438 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multicopper oxidase
EC: 1.10.3.2
UniProt: Q8ZWA8
Ligands: C2O, CU
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multicopper oxidase (EC 1.10.3.2)	protein	438	8% helix, 47% strand	Q8ZWA8

Ligands and binding sites

C2O · Cu-O-Cu linkage · ligand · chains A
CU · Copper (II) ion · metal · 2 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	138	0.52	0.80	20	empty
2	120	0.44	0.77	26	empty
3	52	0.34	0.78	12	empty

Compared structures

3AW5 · Structure of a multicopper oxidase from the hyperthermophilic archaeon Pyrobaculum… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8ZWA8
Elsewhere: RCSB PDB 3AW5 · PDBe 3AW5 · UniProt Q8ZWA8

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