MolNFT v1 · #58135 · protein
Structure of the human myosin-X MYTH4-ferm cassette
3AU5: “Structure of the human myosin-X MYTH4-ferm cassette”. X-ray diffraction, 18 pockets (best druggability 0.80). MolNFT v1 #58135 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3AU5
- Type
- protein
- Length
- 977 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-X
- UniProt
- Q9HD67
- Pockets
- 18 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-X | protein | 493 | 47% helix, 17% strand | Q9HD67 |
| B | Myosin-X | protein | 484 | 46% helix, 14% strand | Q9HD67 |
Pockets
18 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 305 | 0.80 | 0.90 | 38 | empty |
| 2 | 308 | 0.77 | 0.89 | 37 | empty |
| 3 | 205 | 0.65 | 0.84 | 32 | empty |
| 4 | 457 | 0.61 | 0.75 | 50 | empty |
| 5 | 98 | 0.53 | 0.83 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 362 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HD67
- Elsewhere: RCSB PDB 3AU5 · PDBe 3AU5 · UniProt Q9HD67
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