MolNFT v1 · #57859 · protein + RNA
Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state.
3AL0 · Glutamyl-TRNA(GLN) amidotransferase subunit a: “Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state.”. X-ray diffraction, 2 ligands (GSU, ZN), 20 pockets (best druggability 0.80).…
- PDB
- 3AL0
- Type
- protein + RNA
- Length
- 1,592 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamyl-TRNA(GLN) amidotransferase subunit a; ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)…
- EC
- 6.3.5.7, 6.3.5.-, 6.1.1.17
- UniProt
- Q9X0Z9, Q9X100, Q9WY94, Q9X2I8
- Ligands
- GSU, ZN
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamyl-TRNA(GLN) amidotransferase subunit a (EC 6.3.5.7) | protein | 472 | 33% helix, 9% strand | Q9X0Z9 |
| B | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN) amidotransferase subunit B (EC 6.3.5.-) | protein | 482 | 34% helix, 15% strand | Q9X100 |
| C | Glutamyl-TRNA(GLN) amidotransferase subunit C,LINKER, glutamate--tRNA ligase 2 (EC 6.3.5.-, 6.1.1.17) | protein | 564 | 38% helix, 10% strand | Q9WY94, Q9X2I8 |
| E | Trnagln | rna | 74 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.80 | 0.90 | 38 | GSU |
| 2 | 70 | 0.73 | 0.96 | 16 | empty |
| 3 | 256 | 0.71 | 0.85 | 45 | empty |
| 4 | 300 | 0.69 | 0.83 | 44 | empty |
| 5 | 99 | 0.68 | 0.91 | 21 | empty |
Interfaces
5 interfaces between chains.
- A–C · 2849 Ų buried · 20 hydrogen bonds · protein-protein
- C–E · 2462 Ų buried · 50 hydrogen bonds · protein-nucleic
- B–C · 2083 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1348 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 1250 Ų buried · 14 hydrogen bonds · protein-nucleic
Compared structures
- 3AL0 · Crystal structure of the glutamine transamidosome from Thermotoga maritima in the… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9X0Z9 · AlphaFold monomer V2.0 prediction for glutamyl-TRNA(GLN) amidotransferase subunit a… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9X2I8 · AlphaFold monomer V2.0 prediction for glutamate--tRNA ligase 2 (Q9X2I8) · a predicted model of the same protein · chain C against A, TM-score 0.81
- Q9X100 · AlphaFold monomer V2.0 prediction for ASPARTYL/GLUTAMYL-TRNA(ASN/GLN) amidotransferase… · a predicted model of the same protein · chain B against A, TM-score 0.81
- Q9WY94 · AlphaFold monomer V2.0 prediction for glutamyl-TRNA(GLN) amidotransferase subunit C… · a predicted model of the same protein · chain C against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0Z9
- Every structure of UniProt Q9X100
- Every structure of UniProt Q9WY94
- Every structure of UniProt Q9X2I8
- Elsewhere: RCSB PDB 3AL0 · PDBe 3AL0 · UniProt Q9X0Z9 · UniProt Q9X100 · UniProt Q9WY94 · UniProt Q9X2I8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.