MolNFT v1 · #57815 · protein
Structure of gankyrin-S6ATPASE photo-cross-linked site-specifically, and incoporated by genetic code expansion
3AJI · 26S proteasome non-ATPase regulatory subunit 10: “Structure of gankyrin-S6ATPASE photo-cross-linked site-specifically, and incoporated by genetic code expansion”. X-ray diffraction, 4 pockets (best druggability 0.75). MolNFT v1…
- PDB
- 3AJI
- Type
- protein
- Length
- 604 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome non-ATPase regulatory subunit 10; Proteasome (prosome, macropain) 26S…
- UniProt
- Q9Z2X2, Q6ZWN9
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | 26S proteasome non-ATPase regulatory subunit 10 | protein | 229 | 55% helix, 0% strand | Q9Z2X2 |
| B, D | Proteasome (prosome, macropain) 26S subunit, ATPase, 4 | protein | 73 | 59% helix, 3% strand | Q6ZWN9 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 779 | 0.75 | 0.79 | 86 | empty |
| 2 | 152 | 0.51 | 0.79 | 23 | empty |
| 3 | 136 | 0.48 | 0.78 | 23 | empty |
| 4 | 50 | 0.26 | 0.74 | 11 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1264 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1213 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 329 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 104 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 79 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 3AJI · Structure of Gankyrin-S6ATPase photo-cross-linked site-specifically, and incoporated by… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2X2 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 10… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2X2
- Every structure of UniProt Q6ZWN9
- Elsewhere: RCSB PDB 3AJI · PDBe 3AJI · UniProt Q9Z2X2 · UniProt Q6ZWN9
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