MolNFT v1 · #57627 · protein

Crystal structure of the rabbit L-gulonate 3-dehydrogenase (NADH form)

3ADP · Lambda-crystallin: “Crystal structure of the rabbit L-gulonate 3-dehydrogenase (NADH form)”. X-ray diffraction, 1 ligand (NAI), 5 pockets (best druggability 0.59). MolNFT v1 #57627 on GenesisL1: 3D structure, binding sites and…

PDB: 3ADP
Type: protein
Length: 310 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lambda-crystallin
EC: 1.1.1.45
UniProt: P14755
Ligands: NAI
Pockets: 5 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lambda-crystallin (EC 1.1.1.45)	protein	310	55% helix, 12% strand	P14755

Ligands and binding sites

NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	463	0.59	0.74	38	empty
2	200	0.51	0.76	20	empty
3	143	0.42	0.75	31	NAI
4	70	0.30	0.72	14	empty
5	53	0.25	0.72	9	empty

Compared structures

3ADP · Crystal Structure of the Rabbit L-Gulonate 3-Dehydrogenase (NADH Form) · the same entry in another collection · chain A against A, TM-score 1.00
P14755 · AlphaFold monomer V2.0 prediction for lambda-crystallin (P14755) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14755
Elsewhere: RCSB PDB 3ADP · PDBe 3ADP · UniProt P14755

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